Phone:+49 (0)6131 39 27144
Gebäude Biozentrum 1, Hanns-Dieter-Hüsch-Weg 15, 55128 Mainz
To gain a better understanding of the global mechanisms underlying neurodegeneration we will use supercomputing facilities and recently developed High-Performance Computing methods in multivariate Genome Wide Association Studies (GWAS) for the extraction of global patterns, including genetic as well as epigenetic and transcriptional aspects, underlying neurodegenerative diseases i.e. Alzheimer’s, Parkinson’s and Huntington’s disease or Amyotrophic Lateral Sclerosis. Via a trans-Omics evaluation followed by in silico modeling we hope to extract core (biochemical) networks across multiple omic-layers (Genome, Transcriptome, Methylome).