Charlotte Hewel

About me

Charlotte Hewel
+49 6131 39 27144
Biozentrum 1, Hanns-Dieter-Hüsch-Weg 15, 55128 Mainz

Current Project

Bioinformatic support for nanopore sequencing of SARS-CoV-2

Recently, our group got involved in the establishment of nanopore sequencing protocols for the characterization of SARS-CoV-2. We are very happy and excited to support this effort. I collaborate on this project together with Tamer.

NGS-Analysis of mouse resilience data

The molecular basis of resilience is still undergoing active research. To this end, various brain regions have gained significance, among them the hippocampus. For its role in memory and emotion regulation its an interesting target to study key aspects of cellular networks and expression patterns.

List of Publications

Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines. Stephan Weißbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger, Karin Everschor-Sitte, Helen May-Simera and Susanne Gerber. BMC Genomics 22, 62 (2021).

5‘ tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression. Jehn J, Treml J, Wulsch S, Ottum B, Erb V, Hewel C, Kooijmans RN, Wester L, Fast I and Rosenkranz D. RNA 2020, Advance Online Article.

Common miRNA patterns of Alzheimer’s disease and Parkinson’s disease and their probable impact on commensal microbial community of the gut. Hewel C, Kaiser J, Wierczeiko A, Linke J, Reinhardt C, Endres K, Gerber S (2019) Frontiers in neuroscience, 13, 113.

PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation. Jehn J, Gebert D, Pipilescu F, Stern S, Kiefer JST, Hewel C, Rosenkranz D. Communications Biology 2018 1:137

Of Wheat and Men: Changes in Genetic Markers for Celiac Disease Over Time. Hewel C, Kaiser, J, Linke, J. Genomics and Computational Biology, 2018, 4. Jg., Nr. 2, S. e100044-e100044.

unitas: the universal tool for annotation of small RNAs. Gebert D, Hewel C, Rosenkranz D. BMC Genomics 2017 18:644.

Temperature-responsive miRNAs in Drosophila orchestrate adaptation to different ambient temperatures. Fast I, Hewel C, Wester L, Schumacher J, Gebert D, Zischler H, Berger C, Rosenkranz D. RNA 2017 23:1352-1364.