About me
Charlotte Hewel
PhD-student
chhewel@uni-mainz.de
+49 6131 39 27144
Anselm-Franz-von-Bentzel-Weg 3, 55128 Mainz
Current Project
Bioinformatic support for nanopore sequencing of SARS-CoV-2
Recently, our group got involved in the establishment of nanopore sequencing protocols for the characterization of SARS-CoV-2. We are very happy and excited to support this effort. I collaborate on this project together with Tamer.
NGS-Analysis of mouse resilience data
The molecular basis of resilience is still undergoing active research. To this end, various brain regions have gained significance, among them the hippocampus. For its role in memory and emotion regulation its an interesting target to study key aspects of cellular networks and expression patterns.
List of Publications
- Charlotte Hewel, Hanno Schmidt, Stefan Runkel, Wolfgang Kohnen, Susann Schweiger-Seemann, Andre Michel, Sven-Ernoe Bikar, Bodo Plachter, Thomas Hankeln, Matthias Linke, Susanne Gerber: Nanopore adaptive sampling of a metagenomic sample derived from a human monkeypox case doi: https://doi.org/10.1101/2023.03.21.53364 (2023)
- Constance Vennin, Charlotte Hewel, Hristo Todorov, Marlon Wendelmuth, Konstantin Radyushkin, Andre Heimbach, Illia Horenko, Sarah Ayash, Marianne Müller, Susann Schweiger, Susanne Gerber and Beat Lutz. A Resilience-Related Glial-Neurovascular Network Is Transcriptionally Activated after Chronic Social Defeat in Male Mice. Cells, 11(21), 3405; https://doi.org/10.3390/cells11213405 (2022).
- Leonie Frommherz, Katalin Komlosi, Charlotte Hewel, Julia Kopp, Malin Dewenter, Andreas Zimmer, Oliver Bartsch, Matthias Linke, Kristin Technau-Hafsi, Susanne Gerber, Judith Fischer and Cristina Has: Acral ichthyosis associated with amino acid substitution in the C-terminus of keratin 2. Journal of European Academy of Dermatology Venereology (2022)
- Susanne Gerber*, Lucas Pospisil, Stanislav Sys, Charlotte Hewel, Ali Torkamani and Illia Horenko*: Co-inference of data mislabeling reveals improved models in genomics and breast cancer diagnostics, Frontiers in Artificial Intelligence, 4 (193 ) https://doi.org/10.3389/frai.2021.739432, (2022)
- Diego Pascual Cuadrado, Anna Wierczeiko, Charlotte Hewel, Susanne Gerber and Beat Lutz: Dichotomic hippocampal transcriptome after glutamatergic versus GABAergic deletion of the cannabinoid CB1 receptor, Frontiers In Synaptic Neuroscience, 13:660718. doi: 10.3389/fnsyn.2021.660718 (2021)
- Stephan Weißbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger Karin Everschor-Sitte, Helen May-Simera and Susanne Gerber. Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines. BMC Genomics 22, 62 (2021)
- Jehn J, Treml J, Wulsch S, Ottum B, Erb V, Hewel C, Kooijmans RN, Wester L, Fast I, Rosenkranz D. 5' tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression. RNA. 2020 Jun;26(6):694-707. doi: 10.1261/rna.073395.119. Epub 2020 Mar 6. PMID: 32144192; PMCID: PMC7266158.
- Charlotte Hewel, Julia Kaiser, Anna Wierczeiko, Jan Linke, Christoph Reinhardt, Kristina Endres and Susanne Gerber: Common miRNA patterns of Alzheimers disease and Parkinsons disease and their putative impact on commensal gut microbiota. Frontiers in Neuroscience, doi: 10.3389/fnins.2019.00113 (2019).
- Julia Jehn, Daniel Gebert, Frank Pipilescu, Sarah Stern, Julian Simon Thilo Kiefer, Charlotte Hewel & David Rosenkranz. PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation. Commun Biol 1, 137 (2018).
- Hewel C, Kaiser, J, Linke, J. Of Wheat and Men: Changes in Genetic Markers for Celiac Disease Over Time. Genomics and Computational Biology, 2018, 4. Jg., Nr. 2, S. e100044-e100044.
- Gebert, D., Hewel, C. & Rosenkranz, D. unitas: the universal tool for annotation of small RNAs. BMC Genomics 18, 644 (2017).
- Fast I, Hewel C, Wester L, Schumacher J, Gebert D, Zischler H, Berger C, Rosenkranz D. Temperature-responsive miRNAs in Drosophila orchestrate adaptation to different ambient temperatures. RNA. 2017 Sep;23(9):1352-1364. Epub 2017 Jun 19. PMID: 28630141; PMCID: PMC5558905.