Phone:+49 6131 39 20141
Gebäude Biozentrum 1, Hanns-Dieter-Hüsch-Weg 15, 55128 Mainz
Multicellular organisms have diverse cell types. Despite several studies, we still lack the characterization of different cell types, understanding of their functions, state, and diversity. Currently, single-cell technologies enable us to look into these lacking parts. In my research, I am particularly looking for method improvement and development for understanding different cell types from single-cell transcriptomics and epigenomics datasets. In order to understand how different cell types govern mutual regulation, it is also necessary to decipher gene regulatory networks governing the specific state of cells. Hence, I am also implementing mathematics and machine learning approaches to understand gene regulatory networks underlying specific cell states.
Susanne Gerber, Lukas Pospisil, Mohit Navandar and Illia Horenko:Low-cost scalable discretization, prediction and feature selection for complex systems, Science Advances, Vol. 6, no. 5, eaaw0961 DOI: 10.1126/sciadv.aaw0961 (2020)
Laura Domingo-Rodriguez, Inigo Ruiz de Azua, Eduardo Dominguez, Eric Senabre, Irene Serra, Sami Kummer, Mohit Navandar, Sarah Baddenhausen, Clementine Hofmann, Raul Andero, Susanne Gerber, Marta Navarrete, Mara Dierssen, Beat Lutz, Elena Martín-García &Rafael Maldonado: A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Communications 11, 782 (2020). https://doi.org/10.1038/s41467-020-14458-y
Navandar M*, Garding A*, Sahu SK, Pataskar A, Schick S, Tiwari VK 2017. ERK signalling modulates epigenome to drive epithelial to mesenchymal transition. Oncotarget 2017; PMID: 28418928
Shrikant Bhute, Pranav Pande, Sudarshan Anand Shetty, Rahul Shelar, Sachin Mane, Shreyas Kumbhare, Ashwini Gawali, Hemal Makhani, Mohit Navandar, Dhiraj Dhotre, Himangi Lubree, Dhiraj Agarwal, Rutuja Patil, Shantanu Ozarkar, Saroj Ghaskadbi, Chittaranjan Yajnik, Sanjay Juvekar, Govind K Makharia, Yogesh S Shouche 2016. Molecular characterization and meta-analysis of gut microbial communities illustrate enrichment of Prevotella and Megasphaera in Indian subjects. Frontiers in Microbiology 2016; PMID: 27242691